Status:
COMPLETED
High-Resolution Diffusion Tensor Imaging (DTI) of the Cervical Spinal Cord in the Setting of Spinal Cord Injury (SCI)
Lead Sponsor:
University of Utah
Conditions:
Spinal Cord Injury
Cervical Spondylosis With Myelopathy
Eligibility:
All Genders
18-80 years
Brief Summary
The investigators propose a prospective study, designed to analyze the efficacy of High-Resolution Diffusion Tensor Imaging for accurately sensing white matter tracts in subjects with spinal cord inju...
Detailed Description
Spinal cord injury (SCI) can result from trauma as well as degenerative conditions, such as cervical spondylotic myelopathy (CSM). Both have a profound impact on the physical and mental health of the ...
Eligibility Criteria
Inclusion
- For inclusion to the Cervical Spinal Cord (CSM)
- Clinical and Radiographic evidence of cervical spondylotic myelopathy
- 18 to 80 years of age
- Safe and stable clinical scenario to undergo imaging
- Awake, alert patient able to cooperate with physical examination
- Give written informed consent prior to any testing under this protocol
- For inclusion to the Control Group, subject must have:
- No diagnosis of cervical degenerative or traumatic disease
- 30 to 80 years of age
- Ability of volunteers to tolerate 1 hr examination
- For inclusion to the Degenerative Disease Group, subject must:
- Have signs or symptoms consistent with spinal cord injury.
- Be diagnosed with cervical spondylosis (degenerative disease).
- For inclusion to the Traumatic Group, subject must have:
- • A spinal cord injury associated with a traumatic event.
Exclusion
- For exclusion to the Cervical Spinal Cord (CSM):
- Unsafe or unstable clinical scenario
- Prior cervical spine surgery
- History of neurological disease (stroke, multiple sclerosis, peripheral neuropathy, or other neurodegenerative conditions)
- Inability to comply with physical examination
- Contraindications to MRI imaging (metal debris, cardiac pacemaker, etc..)
- Pregnant women
- For exclusion to the other groups:
- Inability to comply with physical examination
- Contraindications to MRI imaging (metal debris, cardiac pacemaker, etc..)
- Pregnant women
Key Trial Info
Start Date :
May 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 1 2014
Estimated Enrollment :
31 Patients enrolled
Trial Details
Trial ID
NCT01407705
Start Date
May 1 2007
End Date
May 1 2014
Last Update
May 21 2014
Active Locations (1)
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1
University of Utah Orthopedics
Salt Lake City, Utah, United States, 84108