Status:
COMPLETED
PET Imaging of Endotoxin-induced iNOS Activation
Lead Sponsor:
Washington University School of Medicine
Collaborating Sponsors:
Barnes-Jewish Hospital
Conditions:
Pneumonia
Eligibility:
All Genders
19-44 years
Phase:
PHASE1
Brief Summary
The overall purpose of this research is to gain understanding of the basic responses of the lung to inflammation. Inflammation is the way our bodies react to irritation or injury, and involves red, wa...
Detailed Description
The investigators plan to use \[18F\](+/-)NOS (the F stands for fluorine and NOS stands for Nitric Oxide Synthase, the name for the investigational radioactive drug that targets iNOS) and positron emi...
Eligibility Criteria
Inclusion
- Healthy man or woman, any race or ethnicity, age 19 - 44 years old
- Screening Pulmonary Function Test
- Screening oxygen saturation by pulse oximetry \>97% on room air
- Capable of lying still and supine within the PET/CT scanner for 1.5 hours
- Capable of following instructions for breathing protocol during CT portion of PET/CT
- Able and willing to give informed consent
- BMI \< 35
Exclusion
- Pregnancy (confirmed by qualitative serum hCG pregnancy test)
- Lactation
- Active menstruation
- History of cardiopulmonary disease
- Currently taking any prescription medications
- History of tobacco use or illicit drug use within the past year
- Presence of implanted electronic medical device
- Enrollment in another research study of an investigational drug
- Known allergy to both trimethoprim/sulfamethoxazole and amoxicillin
- Known allergy to drugs routinely used during bronchoscopy
- Inability lie flat for 1.5 hours for PET/CT scans or follow breathing protocol instructions for the CT portion of the PET/CT
Key Trial Info
Start Date :
December 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2012
Estimated Enrollment :
19 Patients enrolled
Trial Details
Trial ID
NCT01407796
Start Date
December 1 2010
End Date
April 1 2012
Last Update
April 21 2014
Active Locations (1)
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1
Washington University School of Medicne
St Louis, Missouri, United States, 63110