Status:
COMPLETED
Subtotal Versus Total Thyroidectomy for Graves' Disease
Lead Sponsor:
Jagiellonian University
Conditions:
Thyroid
Goiter
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The extent of thyroid resection in Graves' disease remains controversial. The aim of this study was to evaluate long-term results of bilateral subtotal thyroidectomy versus total thyroidectomy in pati...
Detailed Description
Graves' disease was first described in 1835. It is an autoimmune disorder caused by antibodies which bind to thyroid-stimulating hormone (TSH) receptors on the thyroid cell membrane. The overt clinica...
Eligibility Criteria
Inclusion
- planned thyroid surgery for clinically, biochemically and immunologically diagnosed Graves' disease in patients with mild active ophthalmopathy and the posterior aspects of both thyroid lobes appearing normal on ultrasound of the neck.
Exclusion
- previous thyroid or parathyroid surgery,
- recurrent hyperthyroidism after radioiodine ablation,
- history of Graves' disease longer than 24 months,
- thyroid nodules within the posterior aspect/s of thyroid lobe/s,
- suspicion of thyroid cancer,
- inactive Graves' ophthalmopathy,
- moderate to severe active Graves' ophthalmopathy,
- preoperative recurrent laryngeal nerve palsy,
- pregnancy or lactation,
- age \< 18 years, or \> 65 years,
- ASA 4 grade (American Society of Anaesthesiology),
- inability to comply with the follow-up protocol.
Key Trial Info
Start Date :
January 1 2000
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2010
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT01408368
Start Date
January 1 2000
End Date
December 1 2010
Last Update
August 3 2011
Active Locations (1)
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1
Jagiellonian University, College of Medicine, Department of Endocrine Surgery, 3rd Chair of General Surgery
Krakow, Poland, 31-202