Status:
COMPLETED
Effect of Glycemic Variability on Autonomic Tone in Hospitalized Patients With Type 2 Diabetes
Lead Sponsor:
Kathleen Dungan
Conditions:
Type 2 Diabetes
Inpatient
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Glycemic variability has been associated with mortality in hospitalized patients with hyperglycemia. However, it is unknown how modulation of glycemic variability would impact outcomes. One possibilit...
Eligibility Criteria
Inclusion
- Age 18 and above
- Admitted to a general medicine or medicine subspecialty service
- Insulin use (\>20 units/day) or hyperglycemia. Hyperglycemia is defined as glucose greater than 180 mg/dL on at least 2 occasions separated by at least 4 hours apart.
Exclusion
- Type 1 diabetes
- Hospital stay expected less than 48 hours
- Inability to consent
- Pregnancy
- Prisoners
- Previous participation
- Autonomic neuropathy
- Conditions that preclude accurate heart rate variability monitoring: atrial fibrillation, frequent ectopy, congestive heart failure, paced heart rhythms
- Conditions which require lower dose insulin algorithms: end stage renal or liver disease
Key Trial Info
Start Date :
July 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2012
Estimated Enrollment :
42 Patients enrolled
Trial Details
Trial ID
NCT01409239
Start Date
July 1 2011
End Date
December 1 2012
Last Update
December 4 2013
Active Locations (1)
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1
The Ohio State University
Columbus, Ohio, United States, 43210