Status:
COMPLETED
The Effect and Safety of Lisinopril in Non-hypertensive Men With Infertility From Low Sperm Count
Lead Sponsor:
University Of Nigeria Teaching Hospital
Conditions:
Oligospermia
Eligibility:
MALE
24-34 years
Phase:
PHASE2
Brief Summary
This study was conceived in order to explain what the investigators previously observed suggesting that lisinopril, a drug normally used to treat patients with high blood pressure and heart failure, m...
Detailed Description
Introduction. Infertility constitutes the cause for about 16.6% of patients seeking consultations at the primary healthcare level. Male factor infertility accounts for about 50% of all infertility pro...
Eligibility Criteria
Inclusion
- The subjects for this investigation were selected from a volunteer pool of male patients attending the fertility clinic of University of Nigeria Teaching Hospital, Enugu. The criteria for their selection were:
- Inclusion criteria:
- regular attendance and on treatment for low sperm count or oligospermia in the fertility clinic for at least 2 years
- total sperm count at selection from 5 million/ml to 10 million/ml,
- white blood cell (WBC) count less than 1 million per ml of the ejaculate
- evidence of undergone comprehensive investigations to exclude secondary causes of low sperm count, (e) evidence of comprehensive investigations to exclude female factor infertility in the spouse
- an assurance of a personal commitment to continue participating in the study until the end-point was reached and (g) normal blood pressure.
- Exclusion criteria:
- Patients who did not give their consent to participate
- did not meet the diagnostic criteria for oligospermia at the time of recruitment
- failed to fulfill any of the above inclusion criteria, even if the diagnostic criteria are fulfilled.
Exclusion
Key Trial Info
Start Date :
March 1 1998
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2006
Estimated Enrollment :
33 Patients enrolled
Trial Details
Trial ID
NCT01409837
Start Date
March 1 1998
End Date
December 1 2006
Last Update
November 25 2013
Active Locations (1)
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1
University of Nigeria Teaching Hospital, Ituku-Ozalla,
Enugu, Enugu State, Nigeria, 01129