Status:
COMPLETED
Sleep Quality in Mechanically Ventilated Patients
Lead Sponsor:
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Collaborating Sponsors:
Ontario Lung Association
Medtronic - MITG
Conditions:
Respiratory Failure
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
Patients requiring mechanical ventilation in the ICU will undergo three consecutive nights of polysomnography to record sleep patterns while receiving three modes of mechanical ventilation; Proportion...
Eligibility Criteria
Inclusion
- Age 18-75
- received mechanical ventilation \>72 hours
- glasgow coma scale \>10
- acute physiology score \<13
- ready for partial ventilatory support: intact respiratory drive, PaO2/FiO2 ratio \>200 on positive end expiratory pressure (PEEP) less than or equal to 5 cmH2O, and PH of 7.35 to 7.45
- sedation: analgesia at dose not higher than 0.01 mg/kg/hr morphine equivalent x 48 hours, sedation at dose not higher than 0.01 mg/kg/hr lorazepam equivalent x 72 hours.
- anticipate ongoing need for partial ventilatory support for the following 72 hours
Exclusion
- Successful completion of spontaneous breathing trial
- Neurological injury, encephalopathy or abnormal EEG
- History of central sleep apnea
- General anaesthesia within 72 hours from study entry
- Requiring haloperidol \>10 mg/24 hours
- hemodynamically unstable
- sepsis
Key Trial Info
Start Date :
April 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2011
Estimated Enrollment :
13 Patients enrolled
Trial Details
Trial ID
NCT01410149
Start Date
April 1 2007
End Date
December 1 2011
Last Update
August 15 2012
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
London Health Sciences Centre - University Hospital
London, Ontario, Canada, N6A 5A5