Status:
COMPLETED
Vasoprotective Activities of Low-Fat Milk in Individuals With Metabolic Syndrome
Lead Sponsor:
University of Connecticut
Conditions:
Cardiovascular Disease
Metabolic Syndrome
Eligibility:
All Genders
18-50 years
Phase:
NA
Brief Summary
The purpose of this study is to define whether the acute consumption of low-fat milk protects against postprandial vascular endothelial dysfunction by reducing oxidative stress responses that limit ni...
Detailed Description
Cardiovascular disease (CVD) is the leading cause of death in the United States, accounting for \~830,000 deaths annually. Oxidative stress and inflammatory responses are fundamental mechanisms leadin...
Eligibility Criteria
Inclusion
- specific criteria of the metabolic syndrome (waist circumference (102-137 or 88-123 cm for men and women, respectively), fasting triglycerides 150-300 mg/dL, and fasting glucose (110-180 mg/dL)
- BMI: \>30 kg/m2,
- non-dietary supplement users for \>2-mo
- no use of any prescription or over-the-counter medications known to affect vasodilatory responses
- no known history of vascular disease
- nonsmokers
- resting blood pressure \<140 mmHg
- not taking any medications that control hypertension
Exclusion
- lactose-intolerant
- excessive alcohol consumption (\>3 drinks/d or \>10 drinks/wk)
- \>7 h/wk of aerobic activity
- use of medications known to affect carbohydrate or lipid/lipoprotein metabolism
- regular use of any anti-inflammatory medications (e.g. aspirin, non-steroidal anti-inflammatory drugs) or over-the-counter aids (e.g. fish oils)
- women who are pregnant, lactating, and have initiated or changed birth control in the past 3-mo
Key Trial Info
Start Date :
August 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2013
Estimated Enrollment :
21 Patients enrolled
Trial Details
Trial ID
NCT01411293
Start Date
August 1 2011
End Date
October 1 2013
Last Update
January 6 2014
Active Locations (1)
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1
University of Connecticut
Storrs, Connecticut, United States, 06269