Status:
COMPLETED
Acute Impact of Intramuscular (IM) Aripiprazole and Olanzapine on Insulin Resistance in High Risk Prediabetics
Lead Sponsor:
Veterans Medical Research Foundation
Collaborating Sponsors:
Bristol-Myers Squibb
Conditions:
Diabetes
Eligibility:
MALE
40-65 years
Phase:
PHASE4
Brief Summary
Antipsychotic medicines used to treat mental illnesses have been associated with effects on blood sugar control. Laboratory studies have shown that certain medications in particular may alter how insu...
Detailed Description
Antipsychotic medications are those that treat the most severe psychiatric symptoms, such as hallucinations, paranoid thoughts, and delusions. Research shows that some of these medications may put peo...
Eligibility Criteria
Inclusion
- No history of axis I mood, anxiety or psychotic disorder (confirmed by Structured Clinical Interview for DSM-IV), and taking no psychotropics
- Prediabetic, based on a finding of impaired glucose tolerance (2 hour post-load serum glucose 140-199 mg/dl) on a 75 gram standard oral glucose tolerance test within the past 90 days
- Family history of type 2 diabetes mellitus
- BMI 25-35 kg/m2
- Males, ages 40-65 inclusive
- English speaker with ability to provide informed consent
- Nonsmoker
Exclusion
- History of Axis I Mood, Anxiety or Psychotic Disorder or Use of Psychotropics
Key Trial Info
Start Date :
March 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2011
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT01411930
Start Date
March 1 2009
End Date
August 1 2011
Last Update
December 20 2012
Active Locations (1)
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1
VA San Diego Healthcare System
San Diego, California, United States, 92161