Status:
COMPLETED
Exploring Advanced Imaging Techniques to Characterize Botulinum Toxin Diffusion in Human Muscle
Lead Sponsor:
New York Presbyterian Hospital
Conditions:
Stroke
Muscle Spasticity
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
Since the use of botulinum toxin in treating spasticity has already been proven effective, we are now using magnetic resonance imaging to examine the toxin diffusion within muscle (post injection) in ...
Detailed Description
Over the past decade, botulinum toxins (BT) have been extensively used to treat any number of diverse disorders, including functionally significant, focal spasticity in the arm and leg of persons with...
Eligibility Criteria
Inclusion
- diagnosis of UMN disease
- clinically significant spasticity in the gastrocnemius muscle to warrant Botox® injection (made at the discretion of Dr. O'Dell)
- naïve to all botulinum toxins in the lower extremity
Exclusion
- MR incompatibility with implanted ferromagnetic devices.\[Specifically, they may not participate in this study if they have a pacemaker, an implanted defibrillator or certain other implanted electronic or metallic devices. They will be screened by the MRI staff for past surgical procedures to determine the possibility of having an implanted medical or metallic device, shrapnel, or other metal, such as metal in the eye.\]
- Pregnancy or breast feeding
Key Trial Info
Start Date :
March 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2012
Estimated Enrollment :
5 Patients enrolled
Trial Details
Trial ID
NCT01412008
Start Date
March 1 2010
End Date
June 1 2012
Last Update
October 1 2013
Active Locations (1)
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1
New York Presbyterian Hospital/Weill Cornell Medical College
New York, New York, United States, 10065