Status:
COMPLETED
Evolution of Interleukin 7, Fat Mass and Metabolic Profile Before and After Transplantation
Lead Sponsor:
University Hospital, Lille
Conditions:
Immunodeficiency Secondary to Organ Transplantation
Eligibility:
All Genders
18-65 years
Brief Summary
Three different white adipose tissue-related disorders, whether due to its excess (obesity), absence (lipoatrophies) or aberrant distribution (lipodystrophies), are paradoxically able to induce metabo...
Detailed Description
Rationale: Due to their ability to store fatty acids and to secrete numerous pro-inflammatory cytokines, adipocytes appear to be key cells in the regulation of energy metabolism and immune response. M...
Eligibility Criteria
Inclusion
- Male and Female
- More than 18 years old
- BMI inferior to 30 kg/m2
- non diabetic patients who need a kidney or a liver transplantation(Glucose blood level \<1,26 g/L without any antidiabetic drug)
- OR included in the islet transplantation protocol because of a C peptide negative brittle or difficult to treat diabetes.
- cover under the social security
Exclusion
- Unable to receive enlightened information
- Refusal to sign the consent
- Auto immune disease (kidney, liver or chronic inflammatory disease)
- need for a kidney-pancreas transplantation
- Creatinin \> 15 mg / L for patients non concerned by kidney transplantation
- Sepsis
- Oestrogens, raloxifene
- Active alcohol Intoxication
- Cancers or autoimmune diseases;
- Psychiatric Pathology
- Active infection including hepatitis C or HIV;
- Age under 18 years or above 65 years
- Participation in another study excluded the possibility of participating in another protocol
- No cover under the social security
- Pregnant or lactating women
- patients under guardianship, persons deprived of liberty
Key Trial Info
Start Date :
June 9 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 1 2018
Estimated Enrollment :
49 Patients enrolled
Trial Details
Trial ID
NCT01414660
Start Date
June 9 2010
End Date
February 1 2018
Last Update
June 7 2018
Active Locations (5)
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1
Amiens University Hospital
Amiens, France
2
Caen University Hospital
Caen, France
3
Lille University Hospital
Lille, France
4
Reims University Hospital
Reims, France