Status:
COMPLETED
Troponin I Release After High Diuretic Doses
Lead Sponsor:
University of Palermo
Conditions:
ADHF
Eligibility:
All Genders
18-95 years
Phase:
PHASE4
Brief Summary
High values of cardiac troponin (Ct) in acute heart failure (ADHF) identify patients (pts) at higher risk and worsened prognosis. A Ct increase during therapy indicates the need for more appropriate i...
Detailed Description
After randomization, all patients included in the study underwent a complete physical examination, including a careful check of HF signs and symptoms, including BW measurement (in the morning before b...
Eligibility Criteria
Inclusion
- signs/symptoms of heart failure;
- New York Heart Association (NYHA) functional Class III or IV on admission due to an exacerbation of symptoms with at least 1 class deterioration;
- evidence of systolic dysfunction on echocardiographic examination on admission (EF\<45%);
- BNP levels on admission \> 100pg/mL
Exclusion
- NYHA class \< III on admission or without a NYHA class improvement on discharge;
- acute coronary syndrome,
- pulmonary thromboembolism,
- cardiac tamponade,
- pericarditis,
- renal insufficiency (serum creatinine \<2,5 mg/dL, BUN \<60 mg/dL) or those on dialysis;
- chronic liver disease,
- pleuro-pneumonia,
- blood and autoimmune diseases,
- concomitant other important co-morbidity,
- cerebral vascular disease,
- dementia,
- cancer,
- uncompensated diabetes,
- took non-steroid anti-inflammatory drugs (NSAID)
- declining to provide informed consent,
- patients requiring pacemaker implantation and those with issues of excessive alcohol consumption
Key Trial Info
Start Date :
August 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2011
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT01419132
Start Date
August 1 2011
End Date
September 1 2011
Last Update
November 1 2011
Active Locations (3)
Enter a location and click search to find clinical trials sorted by distance.
1
Department of Internal and Specialty Medicine
Palermo, Palermo, Italy, 90127
2
Gaspare PArrinello
Palermo, Palermo, Italy, 90127
3
GF Ingrasasia Hospital
Palermo, Palermo, Italy, 90132