Status:
TERMINATED
Imaging of Brain Receptors Using (11C)mGlu1
Lead Sponsor:
National Institute of Mental Health (NIMH)
Conditions:
Dosimetry
Pharmacokinetics
Eligibility:
All Genders
18-50 years
Phase:
PHASE1
Brief Summary
Background: \- (11C)mGlu1 is a new drug that helps to show where a protein, mGluR1, is found in the brain. The drug contains a small amount of radioactivity that can be detected by imaging studies li...
Detailed Description
Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors that respond to glutamate by activating proteins inside nerve cells that affect cell metabolism, thereby fine-tuning the signa...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Healthy volunteers subjects aged 18 50 with medical history/physical exam, electrocardiogram (ECG), and laboratory tests within normal limits within 60 days of the PET scan.
- EXCLUSION CRITERIA:\<TAB\>
- \<TAB\>Lifetime psychiatric illness or severe systemic disease based on history and physical exam.
- \<TAB\>Serious medical illness likely to modify brain anatomy and/or physiology (seizure disorders, past brain surgery, etc.)
- \<TAB\>High blood pressure, as demonstrated by at least two resting measurements above 140/100, separated by at least 30 min.
- \<TAB\>Any current substance or alcohol abuse, with the exception of nicotine.
- \<TAB\>Positive urine toxicology screen
- \<TAB\>Radiation exposure from participation in other research protocols or clinical care in the last year such that the additional radiation exposure from this protocol would exceed annual limits.
- \<TAB\>Pregnancy or breastfeeding.
- \<TAB\>Claustrophobia (Part 1 only).
- \<TAB\>metallic (ferromagnetic) implants, including pacemakers or other implanted electrical devices, brain stimulators, some types of dental implants, aneurysm clips (metal clips on the wall of a large artery), metallic prostheses (including metal pins and rods, heart valves, and cochlear implants), permanent eyeliner, implanted delivery pump, shrapnel fragments, and possible small metal fragments in the eye (Part 1 only).
- \<TAB\>Unable to lie flat on back for up to 2.5 hours.
- \<TAB\>Positive HIV test.
- \<TAB\>Inability to provide informed consent
Exclusion
Key Trial Info
Start Date :
July 29 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 27 2012
Estimated Enrollment :
3 Patients enrolled
Trial Details
Trial ID
NCT01420952
Start Date
July 29 2011
End Date
November 27 2012
Last Update
December 16 2019
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892