Status:
COMPLETED
Evaluation Of Enoxaparin Pharmacokinetic For Thromboprophylaxis In Burn Care Patients
Lead Sponsor:
Centre hospitalier de l'Université de Montréal (CHUM)
Conditions:
Skin Burn Extensive
Eligibility:
All Genders
18+ years
Brief Summary
OVERVIEW: * Thromboembolisms represent a serious and feared complication in hospitalized patients. * Several factors make the ICU patient population at increased risk of venous thromboembolism. * A h...
Detailed Description
Deep venous thrombosis (DVT) has taken a prevalent place in medical literature over the past decades. In an attempt to decrease its impact on hospitalized patients, multiple trials have tried to bette...
Eligibility Criteria
Inclusion
- Patients age 18 and over
- Burn injuries greater than 20%
- Received at least 24 hours of enoxaparin prior to the sampling series
- Patients admitted to Hôtel-Dieu hospital of the "CHUM: Centre hospitalier de l'Université de Montréal"
Exclusion
- Age less than 18 years
- Pregnancy
- Patients in the postoperative period (within 24 hours of the surgery)
- Patients with a contraindication for heparin use (Heparin induced thrombocytopenia and severe hemorrhage)
- Patients needing therapeutic anticoagulation
- Hepatic insufficiency prior to the burn injury (CHILD-PUGH B or more)
- Patients with a hemoglobin inferior to 70g/L
- Patients with a renal clearance less than 30 ml/min as calculated with the Cockroff-Gault formula prior to the burn care admission.
- Patients without basic French or English comprehension.
Key Trial Info
Start Date :
January 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 1 2013
Estimated Enrollment :
180 Patients enrolled
Trial Details
Trial ID
NCT01421537
Start Date
January 1 2011
End Date
January 1 2013
Last Update
August 3 2020
Active Locations (1)
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1
Centre hospitalier de l'Université de Montréal (CHUM)
Montreal, Quebec, Canada, H2W 1T8