Status:
COMPLETED
Intrapleural Methylprednisolone Injection for Multiple Organ Failure With Acute Respiratory Distress Syndrome
Lead Sponsor:
National Taiwan University Hospital
Conditions:
Acute Respiratory Distress Syndrome (ARDS)
Multiple Organ Failure
Eligibility:
All Genders
16-87 years
Phase:
PHASE2
Brief Summary
Acute respiratory distress syndrome (ARDS) in combination with multi-organ dysfunction syndrome (MODS) is a life-threatening condition, particularly when treatment modalities such as extracorporeal me...
Detailed Description
Acute respiratory distress syndrome (ARDS) with multi-organ dysfunction syndrome (MODS) are common debilitating postoperative complications, which also result from shock and trauma. However, despite t...
Eligibility Criteria
Inclusion
- All of the patients had failure of at least 2 organs acquiring arteriovenous or venovenous ECMO support
- All of the patients met the criteria as below:
- blood gas parameters of PaO2/FiO2 \< 100
- bilateral pulmonary infiltration on chest radiographic images
- 100% oxygen demand in case of ventilation and ECMO flow
- hemodynamic instability requiring high catecholamine infusion
- All the patients had scoring system, which were calculated by the physician within 24 h of admission of the patients into the hospital.
- sequential organ failure assessment score (SOFA) ≥ 10
- Acute Physiology and Chronic Health Evaluation II (APACHE II) score ≥ 20
- inotropic score ≥ 10
- multiple organ dysfunction (MOD) score ≥ 10
Exclusion
- uncontrollable underlying disease
- life expectancy of less than 24 h
- immunosuppression
- neutrophil count of less than 0.3 × 109/L
- brainstem death
- history of long-term corticosteroid use during the past 6 months.
Key Trial Info
Start Date :
June 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2009
Estimated Enrollment :
29 Patients enrolled
Trial Details
Trial ID
NCT01423864
Start Date
June 1 2005
End Date
June 1 2009
Last Update
August 26 2011
Active Locations (1)
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1
Department of Surgery, National Taiwan University Hospital
7, Chung-Shan S. Rd, Taipei 10002, Taiwan., Taiwan, Taiwan, 10002