Status:
COMPLETED
Diet and Systemic Inflammation
Lead Sponsor:
Fred Hutchinson Cancer Center
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
University of Washington
Conditions:
Low-grade Chronic Inflammation
Intestinal Permeability
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
People with chronic low-grade inflammation have a higher risk for certain diseases such as cardiovascular disease or type 2 diabetes. While it is known that obese people are more likely to show signs ...
Detailed Description
The objective of this proposal is to investigate whether fructose-sweetened beverages trigger low-grade systemic inflammation in healthy men and women. Low-grade systemic inflammation, specifically el...
Eligibility Criteria
Inclusion
- Age: 18-65 years;
- BMI 20-40 kg/m2;
- Weight stable to within 10 pounds for 6 months prior to entering the study, and at their lifetime maximum weight (or within 30 pounds of it; excluding pregnancy);
- Ability to be admitted for \~30 minutes on three occasions, and \~6 hours on three occasions to the FHCRC Prevention Center;
- Ability to provide informed written consent;
- Willingness to consume only food and beverages provided by the Human Nutrition Laboratory of the FHCRC Prevention Center for three periods of 8 days each.
Exclusion
- Presence or history of chronic inflammatory, autoimmune or metabolic diseases;
- Presence of phenylketonuria, hereditary fructose intolerance, fructose malabsorption, or malabsorption syndromes;
- Abuse of alcohol (\>2 drinks per day), smoking, or use of recreational drugs;
- Current or recent (within three months) intake of medications likely to interfere with study endpoints (insulin, antidiabetics, β-blockers, anabolic steroids, glucocorticosteroids, daily high-dose non-steroidal anti-inflammatory drugs, warfarin, antibiotics, probiotics);
- Presence of anemia, recent (within 2 months) history of anemia;
- Anyone not willing or able to eat the provided food;
- Current or recent (within 12 months) pregnancy or breastfeeding.
Key Trial Info
Start Date :
October 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2014
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT01424306
Start Date
October 1 2011
End Date
April 1 2014
Last Update
August 14 2017
Active Locations (1)
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1
Fred Hutchinson Cancer Research Center
Seattle, Washington, United States, 98109