Status:
UNKNOWN
Effects of Somatostatin on Post-endoscopic Portal Hemodynamic in Cirrhotic Patients With Esophageal Gastric Varices
Lead Sponsor:
Yunsheng Yang
Conditions:
Esophageal Varices Secondary to Cirrhosis of Liver
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
The main complications of cirrhosis are ascites, esophageal varices and hepatic encephalopathy. About 30% to 70% patients with cirrhosis occur esophageal varices, and the most common complication is a...
Detailed Description
126 patients will be enrolled in the study, 63 subjects will be randomized into the group A and the other will be into the group B. Group A: endoscopic therapy and somatostatin treatment. Group B: en...
Eligibility Criteria
Inclusion
- Cirrhosis with esophageal gastric varices needed endoscopic therapy
- Age 18-75 years
- Informed written consent
Exclusion
- Use of vasoactive drugs 24 hours before endoscopic treatment
- Use of B-blocker within 1 week
- Previous surgical or endoscopic treatment for esophageal gastric varices
- Hepatic encephalopathy,comatose status and any other disease which could not accept endoscopic therapy
- Gastro-renal vein shunt
- Severe hepatic hydrothorax
- Hepatocellular carcinoma with portal vein thrombosis
- Severe coagulation disorders
- Severe active bacteria infection
- Severe cardiovascular disease, including a history of acute myocardial infarction,heart block, heart failure
- Severe renal function insufficiency （Calculated Creatinine Clearance Rate (Ccr) \<30ml/min）
- Severe co-morbidity that would affect short-term prognosis
- Pregnancy or lactation
- Allergy to any ingredient of trial medication
- Medical or psychological condition that would not permit the patient to complete the study or sign the informed consent
Key Trial Info
Start Date :
July 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2012
Estimated Enrollment :
126 Patients enrolled
Trial Details
Trial ID
NCT01426087
Start Date
July 1 2011
End Date
December 1 2012
Last Update
September 2 2011
Active Locations (1)
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1
Site
Beijing, China, 010