Status:
COMPLETED
Intravenous N-acetylcysteine for the Treatment of Gaucher's Disease and Parkinson's Disease
Lead Sponsor:
University of Minnesota
Collaborating Sponsors:
Rare Diseases Clinical Research Network
National Center for Advancing Translational Sciences (NCATS)
Conditions:
Parkinson's Disease
Gaucher's Disease
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
The investigators are interested in determining if the investigators are able to detect changes in brain chemistry using Magnetic Resonance Spectroscopy (MRS) in individuals with Parkinson's disease (...
Detailed Description
Oxidative stress is implicated in the pathogenesis of a number of neurodegenerative diseases such as Parkinson's disease (PD). Further, levels of glutathione (GSH), a prevalent endogenous antioxidant,...
Eligibility Criteria
Inclusion
- All participants must be 18 years or older.
- All enrollees must understand and cooperate with requirements of the study in the opinion of the investigators and must be able to provide written informed consent.
- Individuals with medically stable Parkinson's disease (in the opinion of the investigator).
- All participants must not have taken antioxidants coenzyme Q-10, vitamin C, or vitamin E for 3 weeks prior to the study.
- Absence of dementia in all subjects, as determined by pre-scanning cognitive assessment.
- Control subjects who are able to undergo MRS
Exclusion
- Inability to undergo MRI scanning without sedation
- Medically unstable conditions in any group as determined by the investigators
- Pregnant or lactating or those women of child-bearing age that are not using acceptable forms of contraception
- Diagnosis of asthma that is presently being treated with ANY medication, or past history of asthma/bronchospasm resulting in an emergency room visit, hospitalization or treatment
- Unable to adhere to study protocol for whatever reason
Key Trial Info
Start Date :
July 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2012
Estimated Enrollment :
9 Patients enrolled
Trial Details
Trial ID
NCT01427517
Start Date
July 1 2011
End Date
December 1 2012
Last Update
November 1 2019
Active Locations (1)
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1
University of Minnesota
Minneapolis, Minnesota, United States, 55455