Status:
UNKNOWN
A Prospective Study to Evaluate the Effect of Chronic Nitrate Therapy on Vasodilation Function in Coronary Heart Disease
Lead Sponsor:
Zhejiang University
Conditions:
Coronary Artery Disease
Eligibility:
All Genders
18-80 years
Brief Summary
Basic studies has showed that sustained use of nitrates might associated with adverse effects on vascular function mediated by an increase in nitrate-induced oxidative stress. But it remains unclear w...
Detailed Description
Organic nitrates are widely prescribed for the treatment of angina pectoris in patients with coronary artery disease (CAD). In China, many patients with CAD are prescribed nitrates as a long-term trea...
Eligibility Criteria
Inclusion
- Individuals were considered eligible for enrollment if they had at least 1 significant de novo stenosis (reduction ≥50% of the lumen diameter) on any coronary vessel at angiography.
Exclusion
- Patients with liver and renal failure with creatinine\>3 mg/dL were excluded.
Key Trial Info
Start Date :
August 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2013
Estimated Enrollment :
68 Patients enrolled
Trial Details
Trial ID
NCT01430780
Start Date
August 1 2009
End Date
December 1 2013
Last Update
March 22 2013
Active Locations (1)
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1
Department of Cardiology, First Affiliated Hospital, College of Medicine, Zhejiang University
Hangzhou, Zhejiang, China, 310003