Status:
TERMINATED
Muscle Biopsies in Healthy Volunteers
Lead Sponsor:
National Institute on Aging (NIA)
Conditions:
Sarcopenia
Frailty
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Background: \- In individuals as they age, changes in muscle tissue can significantly affect their muscle strength and exercise endurance. This process, known as sarcopenia, may lead to decreased mob...
Detailed Description
An important concept in pathologic aging is that in some individuals muscle strength and exercise endurance are significantly decreased through both quantitative and qualitative changes in muscle tiss...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Healthy volunteers over the age of 18
- Normal screening laboratory studies including CBC, chem. 12 panel, PT/PTT, INR, UA, EKG
- Ability to provide informed consent
- EXCLUSION CRITERIA:
- No history of bleeding diathesis
- Subject is not on heparin, coumadin, plavix, or other anticoagulant
- Subjects taking aspirin or non-steroidal anti-inflammatory agents must stop these 7 days before the biopsy
- No allergy to lidocaine or bupivacaine
- Subject has no active infections or chronic skin conditions that prevent access to the biopsy area
- Unable to provide informed consent
- No antibiotics for the past week
- Positive pregnancy test
- Positive for HIV, and/or positive for hepatitis B or C
Exclusion
Key Trial Info
Start Date :
May 17 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 29 2014
Estimated Enrollment :
22 Patients enrolled
Trial Details
Trial ID
NCT01431677
Start Date
May 17 2010
End Date
July 29 2014
Last Update
December 17 2019
Active Locations (1)
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1
National Institute of Aging, Clinical Research Unit
Baltimore, Maryland, United States, 21224