Status:
COMPLETED
Distribution of Rubidium-82, Nitrogen-13 Ammonia, and Fluorine-18 Fluorodeoxyglucose in Normal Volunteers
Lead Sponsor:
University of Michigan
Conditions:
Heart Disease
Eligibility:
All Genders
30-70 years
Phase:
PHASE1
Brief Summary
Establish the normal distributions of Rb-82, N-13 ammonia, and F-18 FDG (radioactive tracers) in the heart using PET imaging. These tracers would be eventually used in evaluating the hearts of patient...
Detailed Description
Cardiac rubidium-82(Rb-82)and N-13 ammonia heart perfusion (blood flow) studies and florine-18 fluorodeoxyglucose (F-18FDG) heart PET glucose metabolism studies are important tools for evaluating pati...
Eligibility Criteria
Inclusion
- Healthy normal volunteers
Exclusion
- Prior participation in a study with significant radiation exposure
- Significant radiation exposure for other reasons, example: routine medical care
- Medical history of physical or treadmill exercise stress EKG evidence of heart or vascular disease.
- Cardiac A-V conduction abnormalities
- Diabetes Mellitus
- Liver Disease
- Kidney Disease
- Other chronic debilitating illnesses ( Example: Rheumatoid Arthritis, Emphysema, Parkinson's Disease).
- Tobacco use, hypertension, diabetes, family history of coronary artery disease before age 45 in males and 55 in females or other coronary risks factors of more than mild severity
- Claustrophobia (fear of tight spaces)
- Pregnancy
- Inability to lay flat with your arms positioned next to your head for approximately 20 minutes.
- Morbid Obesity
- Asthma
- Breasts Implants
- Use of anabolic steroids
- Use of recreational drugs
Key Trial Info
Start Date :
November 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 19 2018
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT01433705
Start Date
November 1 2011
End Date
January 19 2018
Last Update
January 30 2019
Active Locations (1)
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1
University of Michigan Hospital
Ann Arbor, Michigan, United States, 48109