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Status:

COMPLETED

DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings

Lead Sponsor:

Children's Oncology Group

Collaborating Sponsors:

National Cancer Institute (NCI)

Conditions:

Childhood Malignant Ovarian Germ Cell Tumor

Childhood Malignant Testicular Germ Cell Tumor

Eligibility:

All Genders

Up to 19 years

Brief Summary

This research trial studies deoxyribonucleic acid (DNA) samples from younger patients with germ cell tumor and their parents or siblings. Studying samples of tumor tissue and saliva from patients with...

Detailed Description

OBJECTIVES: I. To evaluate associations between genetic variation and pediatric germ cell tumor (GCT) using a case-parent triad design to identify variants in four genes, KITLG, SPRY4, BAK1, and DMRT...

Eligibility Criteria

Inclusion

  • Inclusion Criteria:
  • The patient is enrolled on COG-ACCRN07
  • The patient has a primary diagnosis of germ cell tumor (GCT) including germinoma (ICCC 9060-9065) teratoma (9080-9084), embryonal carcinoma (9070-9072), yolk sac tumor (9071),choriocarcinoma (9100, 9103, 9104), and mixed GCT (9085, 9101, 9102, 9105) in all sites including the brain and central nervous system and registered with Children's Oncology Group (COG) by a North American member institution
  • The patient must be diagnosed with a germ cell tumor between July 1, 2008 and December 31, 2015
  • The patient must be \< 20 years of age at the time of diagnosis
  • The patient must have at least one biological parent alive and willing to participate
  • In the event that one case parent cannot contribute DNA, a case sibling, defined as the biological brother or sister of the study subject, may donate instead
  • All questionnaire respondents must understand English or Spanish
  • Concomitant treatment on a therapeutic trial is not required

Exclusion

    Key Trial Info

    Start Date :

    November 1 2011

    Trial Type :

    OBSERVATIONAL

    Allocation :

    ESTIMATED

    End Date :

    August 4 2016

    Estimated Enrollment :

    932 Patients enrolled

    Trial Details

    Trial ID

    NCT01434355

    Start Date

    November 1 2011

    End Date

    August 4 2016

    Last Update

    January 7 2019

    Active Locations (1)

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    Childrens Oncology Group

    Philadelphia, Pennsylvania, United States, 19104