Status:
UNKNOWN
Breath Test for Patients With Acute Liver Disease for Early Detection of the Need for Transplant or Recovery
Lead Sponsor:
Hadassah Medical Organization
Conditions:
Acute Liver Failure
Eligibility:
All Genders
18+ years
Brief Summary
Acute liver failure (ALF) results from an abrupt loss of hepatic metabolic and synthetic function and leads to encephalopathy and potentially multi-organ dysfunction. Aetiologies include autoimmune an...
Eligibility Criteria
Inclusion
- Adult men or women (\>18 years of age).
- Acute Liver insult
- No evidence of cirrhosis (unless clinical acute Wilsons)
- INR \> 1.5
- Duration of illness \< 24 weeks -
Exclusion
- Patient with any chronic liver disease
- Patient has severe congestive heart failure
- Patient has severe pulmonary hypertension
- Patient has chronic renal insufficiency with severe cardiac disease
- Patient has previous surgical bypass surgery for morbid obesity
- Patient has extensive small bowel resection
- Patient with established extra-hepatic auto-immune disease on long term treatment
- Patient is a recipient of any organ transplant (within the last 3 months)- Patient with proven or suspected hepatocellular carcinoma
- Patient is pregnant
- Patient allergic to paracetamol (such as Tylenol or any other related medications)
- Patients in whom oral intake is contra-indicated
- Patient, based on the opinion of the investigator, should not be enrolled into this study
- Patients or their nominated representative is unwilling to sign informed consent
- Patients that are participating in other clinical trials evaluating experimental treatments or procedures, not including observatory trials -
Key Trial Info
Start Date :
October 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
112 Patients enrolled
Trial Details
Trial ID
NCT01435421
Start Date
October 1 2011
Last Update
September 16 2011
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