Status:
COMPLETED
Can Short Latency Afferent Inhibition Give us Clues to Better DYT 1 Dystonia Treatments?
Lead Sponsor:
University of Florida
Collaborating Sponsors:
Brain and Spinal Cord Injury Research Trust Fund
Conditions:
DYT-1
DYT1
Eligibility:
All Genders
10-80 years
Brief Summary
This is a research study using transcranial magnetic stimulation (TMS) to investigate interactions between the sensory system and the motor cortex in primary generalized dystonia (DYT1 dystonia) subje...
Detailed Description
The cause of DYT1 dystonia is not clear. DYT1 dystonia symptoms include abnormal posture or repetitive twisting movements affecting one body part; in some patients, the entire body can twist and conto...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Between the ages of 10 and 80 years. (CONTROL SUBJECTS between 18-80 years)
- Diagnosis and genetic test results confirming diagnosis of DYT1 dystonia.
- Currently treated with medications and enrolled in evaluation process for DBS surgery to confirm candidacy - OR -
- Previous DBS surgery
- EXCLUSION CRITERIA:
- Implanted pacemaker, medication pump, vagal stimulator, Transcutaneous electrical nerve stimulation (TENS) unit or ventriculoperitoneal shunt.
- Family or personal history of medication refractory epilepsy.
- Pregnancy: due to the frequent visits over a prolonged period and the lack of Information on the safety of TMS during pregnancy, pregnant women will not be eligible to participate in this study. Women of childbearing potential will be eligible to participate, provided that they are using adequate contraception during TMS treatments.
- This study is accepting healthy volunteers, aged 18-80, as control subjects. Control subjects will not undergo DBS surgery.
- EXCLUSION CRITERIA (as it applies to healthy control subjects):
- Cannot have family history or personal history of medication refractory epilepsy
Exclusion
Key Trial Info
Start Date :
May 1 2012
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 1 2016
Estimated Enrollment :
5 Patients enrolled
Trial Details
Trial ID
NCT01435681
Start Date
May 1 2012
End Date
August 1 2016
Last Update
September 8 2016
Active Locations (1)
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1
UF Center for Movement Disorders and Neurorestoration
Gainesville, Florida, United States, 32607