Status:
COMPLETED
The Effects of Sertraline on Depression in Parkinson's Disease
Lead Sponsor:
Zhejiang University
Conditions:
Depression
Parkinson's Disease
Eligibility:
All Genders
35-75 years
Phase:
NA
Brief Summary
The aim of this open-label, self-control study is to evaluate the efficacy of sertraline in treating depression in Patients with Parkinson's disease. In addition, the investigators also want to find o...
Detailed Description
Depression in PD is associated with more severe cognitive and functional impairments, a faster progression of illness, worse quality of life, increase mortality and higher burden for caregivers, when ...
Eligibility Criteria
Inclusion
- Patients between 35 and 75 years of age from the outpatients clinic in Department of Neurology, the Second Affiliated Hospital, School of Medicine, Zhejiang University.
- All patients should have a confirmed diagnosis of PD according to Brain Bank Criteria.
- Diagnosed to be major depression episode according to DSM-IV,
- Mini Mental State Examination (MMSE) exclude dementia.
Exclusion
- Mini-Mental State Examination (MMSE) demonstrate dementia
- Any current DSM-IV Axis I diagnosis other than a depressive or anxiety disorder.
- History of psychosis or hallucinations or under treatment with atypical neuroleptics.
- Treatment-resistant depression. Treatment-resistant depression (TRD) occurs when a patient with unipolar depression fails to respond to adequate antidepressant therapy.
- Pregnancy or lactation.
- Concomitant use in patients taking monoamine oxidase inhibitors (MAOIs).
- Concomitant use in patients taking pimozide.
Key Trial Info
Start Date :
August 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2013
Estimated Enrollment :
35 Patients enrolled
Trial Details
Trial ID
NCT01437189
Start Date
August 1 2011
End Date
November 1 2013
Last Update
January 30 2024
Active Locations (1)
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1
Department of Neurology, the Second Affiliated Hospital, School of Medicine, Zhejiang University
Hangzhou, Zhejiang, China, 310009