Status:
COMPLETED
The Effect and Safety of Different Intensity Anticoagulation Therapy in Elderly Patients With Non-valvular Atrial Fibrillation
Lead Sponsor:
Nanjing Medical University
Conditions:
Atrial Fibrillation
Eligibility:
All Genders
75-94 years
Phase:
PHASE4
Brief Summary
Current guidelines recommend standard warfarin anticoagulation international normalized ratio (INR) goal of 2.0-3.0 in adults with non valvular atrial fibrillation (NVAF). The investigators hypothesiz...
Detailed Description
Atrial fibrillation is the commonest chronic arrhythmia in clinical practice, especially in octogenarians. Nonvalvular atrial fibrillation increases the risk of ischemic stroke by approximately 5-fold ...
Eligibility Criteria
Inclusion
- Clinical diagnosis of atrial fibrillation
- Echocardiography confirmed a non-valvular heart disease
- Age≥75 years
Exclusion
- Unable to cooperate with doctors
- Life expectancy of less than 1 year
- Rheumatic heart disease or dilated cardiomyopathy
- History of artificial valve replacement surgery
- Infectious endocarditis
- Stroke or transient ischemic attack(TIA) within the last 6 months
- Previous history of intracranial hemorrhage, gastrointestinal, respiratory or urogenital bleeding
- Previous intolerance/allergy to warfarin or aspirin
- Blood pressure greater than 180/110 mmHg
- Chronic liver dysfunction, alanine aminotransferase above the normal reference value of the upper limit 3 times
- Chronic renal failure, serum creatinine clearance rate (Ccr) less than 30 ml / min
- Patient was receiving antiplatelet or anticoagulant therapy due to other reasons
Key Trial Info
Start Date :
January 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2012
Estimated Enrollment :
260 Patients enrolled
Trial Details
Trial ID
NCT01438580
Start Date
January 1 2010
End Date
April 1 2012
Last Update
May 21 2012
Active Locations (1)
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1
First Affiliated Hospital of Nanjing Medical University, Division of Geriatrics
Nanjing, Jiangsu, China, 210029