Status:
COMPLETED
Prevalence and Early Markers of Atherosclerosis in Adults With a History of Kawasaki Disease
Lead Sponsor:
Hospices Civils de Lyon
Conditions:
Kawasaki Disease
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
Kawasaki disease (KD) is an acute systemic vasculitic syndrome with coronary tropism. It has been reported worldwide, but it is ten times more common in Asian population. The annual incidence in chil...
Eligibility Criteria
Inclusion
- History of KD before the age of 18, with or without macroscopic coronary lesions in the childhood phase. (KD group only)
- 18 years old or older at the time of the study.
- Agree on participating to all explorations of the study.
- Accept genotyping.
- Absence of cardiovascular risk factors
Exclusion
- Atypical KD (KD group only)
- Documented or suspected coronary ischemia,
- Refusal to participate to the study or sign the consent
- Contra-indication to the injection of iodinated contrast agents (allergy, renal failure)
- Hypersensitivity to dobutamine,
- No effective contraception method for females with child bearing potential,
- Breastfeeding, or pregnant females,
- Treatment modifying endothelial reactivity
- History of severe intolerance to iodinated contrast agents,
- Subjects who can't hold their breath for at least 20 seconds,
- Irregular or absence of sinus rhythm, especially atrial or ventricular arrhythmia
- Unability to give information to the subject,
- No coverage from a Social Security system
- Deprivation of civil rights
Key Trial Info
Start Date :
October 10 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 13 2015
Estimated Enrollment :
43 Patients enrolled
Trial Details
Trial ID
NCT01440075
Start Date
October 10 2011
End Date
April 13 2015
Last Update
August 22 2017
Active Locations (1)
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1
Hopital cardiologique Louis Pradel
Bron, France, 69677