Status:
COMPLETED
Loop Diuretics Administration and Acute Heart Failure
Lead Sponsor:
University of Siena
Conditions:
Acute Heart Failure
Eligibility:
All Genders
18-100 years
Phase:
PHASE4
Brief Summary
Intravenous loop diuretics is the therapy most commonly used to treat pulmonary congestion and systemic fluid overload. In theory, continuous infusion should allow for a more consistent diuresis, avoi...
Detailed Description
Patients were eligible if they were admitted with a primary diagnosis of ADHF, randomized within 12 h after hospital presentation, and with evidence of volume overload (pulmonary congestion) on a ches...
Eligibility Criteria
Inclusion
- Patients took part in the random sample selection if they met the diagnostic criteria for acute decompensated HF.
- Patients with primary diagnosis of ADHF, volume overload with cardia dilation and LVEF \<50%, and had BNP levels \>100 pg/ml.
Exclusion
- Patients were excluded if they had received more than 2 IV doses of furosemide or any continuous infusion of furosemide 1 month before randomization
- If they had end-stage renal disease or the need for renal replacement therapy, isolated diastolic dysfunction.
- Recent myocardial infarction
Key Trial Info
Start Date :
April 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 28 2017
Estimated Enrollment :
57 Patients enrolled
Trial Details
Trial ID
NCT01441245
Start Date
April 1 2010
End Date
December 28 2017
Last Update
January 23 2018
Active Locations (1)
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1
Department of Internal Medicine, Cardiology Section Center
Siena, Italy, 53100