Status:
COMPLETED
Strength Training and Nutrition Development for African American Youth
Lead Sponsor:
University of Southern California
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Obesity
Type 2 Diabetes
Eligibility:
All Genders
14-18 years
Phase:
NA
Brief Summary
The investigators are conducting an intervention study to examine the effects of a 16-week exercise and diet interventions on prevention of disease, specifically type 2 diabetes and heart disease, in ...
Detailed Description
A.1 Aims The overall goal of this project is to examine role of strength training as a therapeutic intervention to improve the cancer and obesity-related metabolic risk profile in African-American ad...
Eligibility Criteria
Inclusion
- Overweight (≥85th BMI percentile)
- African American: Children will initially be defined as African American if they and both parents and all 4 grandparents self identify as African American.
Exclusion
- Diabetes: Children will not be eligible for participation if they have any diagnostic criteria for diabetes, including polyuria, polydipsia with or without unexplained weight loss, fasting plasma glucose \>126 mg/dl, or a 2-hour plasma glucose \>200 mg/dL during an OGTT using a dose of 1.75g glucose/kg BW (to a maximum of 75g). Children will also be excluded if they test positive for diabetes-related auto-antibodies, including ICA512 and GAD. Children testing positive for type 2 diabetes will be referred for treatment. Children with impaired glucose tolerance (fasting glucose \>100 mg/dL or 2-hour glucose \>140 mg/dl during an oral glucose tolerance test) and/or conditions associated with insulin resistance (e.g. acanthosis nigricans, hypertension, dyslipidemia, poly-cystic ovarian syndrome) will be eligible, as long as they are not receiving treatment and meet other eligibility criteria.
- Weight loss or exercise program: currently involved with any weight loss or exercise program, or have been in the 6 months prior to participation
- Use of medications: taking any medications known to influence body composition or insulin action/secretion (e.g. prednisone, ritalin, growth hormone)
- Syndromes that influence body composition: diagnosed with syndromes or diseases that may influence body composition and fat distribution (e.g. Cushing syndrome, Down syndrome)
Key Trial Info
Start Date :
June 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2008
Estimated Enrollment :
62 Patients enrolled
Trial Details
Trial ID
NCT01441323
Start Date
June 1 2007
End Date
December 1 2008
Last Update
March 31 2017
Active Locations (1)
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1
Veronica Atkins Lifestyle Intervention Laboratory
Los Angeles, California, United States, 90033