Status:
TERMINATED
APOL1 Gene Variants in African American Kidney Transplant Recipients
Lead Sponsor:
Brigham and Women's Hospital
Conditions:
Transplant;Failure,Kidney
Kidney Disease
Eligibility:
All Genders
18+ years
Brief Summary
Aim 1: Determine if there is an association between the APOL1 risk variants and allograft survival and function in African Americans Aim 2: Determine if there is an association between the presence...
Eligibility Criteria
Inclusion
- Aim 1:
- Inclusion Criteria:
- self-reported African American
- 18 years or older
- kidney transplant within 12 years
- Aim 2:
- Inclusion Criteria for patients with recurrent disease:
- self-reported African American
- 18 years or older
- kidney transplant within 12 years
- recurrent or de novo glomerular disease on allograft kidney biopsy
- Inclusion Criteria for control group:
- self-reported African American
- 18 years or older
- kidney transplant within 12 years
- end stage kidney disease due to glomerular nephritis, clinically diagnosed or by native kidney biopsy
- Exclusion Criteria for control group:
- clinical evidence of recurrent disease (presence of proteinuria, hematuria, Creatinine \>2)
- Aim 3:
- Inclusion Criteria:
- self-reported African American
- 18 years or older
- scheduled living kidney transplant
Exclusion
Key Trial Info
Start Date :
April 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 1 2014
Estimated Enrollment :
39 Patients enrolled
Trial Details
Trial ID
NCT01442402
Start Date
April 1 2014
End Date
April 1 2014
Last Update
January 27 2021
Active Locations (1)
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1
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115