Status:
COMPLETED
Chloroquine for Malaria in Pregnancy
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)
Conditions:
Malaria
Eligibility:
FEMALE
Up to 99 years
Phase:
PHASE3
Brief Summary
The purpose of this study is to test prevention strategies for pregnancy-related malaria. Researchers will compare different malaria treatments and treatment schedules which include chloroquine therap...
Detailed Description
In areas of high malaria endemicity, typical of much of sub-Saharan Africa, despite having achieved semi-immunity to malaria in adulthood, women become vulnerable to malaria infection during pregnancy...
Eligibility Criteria
Inclusion
- Women who present to the Ndirande Antenatal Clinic (ANC) and meet the following inclusion criteria will be enrolled in the study: -Before the end of 27th week of gestation -First or second pregnancy -Anticipate remaining in Blantyre until 14 weeks after delivery -Agree to deliver at the Ndirande Health Centre or Queen Elizabeth Central Hospital (QECH) -Provision of informed consent
Exclusion
- Chronic use (\>14 days) of any medication with antimalarial or antifolate activity -Human immunodeficiency virus (HIV) infection -Known high-risk pregnancy requiring regular supervision of an obstetrician -Allergy to any of the study drugs
Key Trial Info
Start Date :
February 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2015
Estimated Enrollment :
900 Patients enrolled
Trial Details
Trial ID
NCT01443130
Start Date
February 1 2012
End Date
January 1 2015
Last Update
December 28 2016
Active Locations (1)
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1
Blantyre Malaria Project - Queen Elizabeth Central Hospital
Blantryre, Blantyre, Malawi