Status:
COMPLETED
High MAP in Septic Shock With Hypertension
Lead Sponsor:
Southeast University, China
Conditions:
Septic Shock
Eligibility:
All Genders
18-90 years
Phase:
NA
Brief Summary
We hypothesized that the increase in MAP from 65 mmHg to patients' usual level improved sublingual microcirculation.
Detailed Description
The effect of mean arterial pressure (MAP) titration to higher level on microcirculation in septic shock patients with previous hypertension remains unknown. Our goal was to assess the effect of MAP t...
Eligibility Criteria
Inclusion
- Patients with septic shock for less than 24 hours
- Fluid resuscitation was performed according to the guideline for treating septic shock to maintain the central venous pressure (CVP) for more than 8 mm Hg and central venous oxygen saturation for more than 70%
- Patients requiring norepinephrine (NE) to maintain a MAP of 65 mm Hg. Septic shock patients with fluid resuscitation after CVP \> 8mmHg and mean blood pressure \> 65 mmHg
Exclusion
- Pregnancy
- Age \< 18 years
- Inability to acquire the usual level of MAP
- Refusal of consent by the patient or relative
- Participation in other trials during the last three months
- Hypertensive patients without hypertension treatment
Key Trial Info
Start Date :
June 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2012
Estimated Enrollment :
19 Patients enrolled
Trial Details
Trial ID
NCT01443494
Start Date
June 1 2011
End Date
June 1 2012
Last Update
July 6 2017
Active Locations (1)
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1
Zhongda Hospital Southeast University
Nanjing, Jiangsu, China, 210000