Status:
COMPLETED
Impact of Dairy Consumption on Inflammation: a Clinical Study (PLI)
Lead Sponsor:
Laval University
Collaborating Sponsors:
Dairy Farmers of Canada
Conditions:
Cardiovascular Disease
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
Inflammation and endothelial dysfunction are being increasingly recognized as key etiological factors in the development of atherosclerosis and subsequent cardiovascular disease (CVD). These pro-ather...
Detailed Description
This research will be undertaken as a multicenter randomized cross-over controlled study. A total of 140 men and women with subclinical inflammation (plasma CRP 2-10 mg/l) but otherwise healthy will c...
Eligibility Criteria
Inclusion
- Men and women aged between 18 and 70 years
- Presenting a subclinical inflammation (Plasma CRP \>2 and \<10 mg/l)
- Abdominal obesity, waist girth \>94 cm in men and \>80 cm in women
- Consumption of dairy products fewer than 2 servings per day
- Pre-menopausal women with regular menstrual cycle for the last 3 months
Exclusion
- Plasma CRP \<2 or \>10 mg/l
- Smokers (\>1 cigarette/day)
- Body weight variation \>10% for the last 6 months prior to the study baseline
- BMI \>35 kg/m2
- Previous history of CVD, type 2 diabetes and monogenic dyslipidemia
- Subjects taking medications for hyperlipidemia, hypertension
- Post menopausal women who have initiated hormone replacement therapy within 6 months of study onset
- Endocrine or gastrointestinal disorders
- Smoking
- Food allergies, milk aversion or intolerant to lactose
- Clinical use of vitamin D or calcium supplements
- Vegetarianism
Key Trial Info
Start Date :
March 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2013
Estimated Enrollment :
140 Patients enrolled
Trial Details
Trial ID
NCT01444326
Start Date
March 1 2010
End Date
December 1 2013
Last Update
April 2 2014
Active Locations (1)
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1
Institute of Nutraceutical and Functional Foods (INAF), Laval University
Québec, Quebec, Canada, G1V 0A6