Status:
COMPLETED
Fructose Consumption and Metabolic Dysregulation
Lead Sponsor:
Marja-Riitta Taskinen
Collaborating Sponsors:
Sahlgrenska University Hospital
Lund University
Conditions:
Central Obesity
Hypertriglyceridemia
Eligibility:
MALE
20-60 years
Phase:
NA
Brief Summary
High fructose intake is increasingly recognized as causative in development of prediabetes, metabolic syndrome and cardiovascular disease (CVD). The mechanisms underlying fructose-induced metabolic di...
Detailed Description
Detailed description: Study subjects will participate to studies 1-4 before and 3 m after fructose diet: 1. An oral fat load or a kinetic study with stable isotopes combined with an oral fat load. 2....
Eligibility Criteria
Inclusion
- Body mass index 27-40
- Waist \> 96 cm
- Age 20-60 years
- Male
Exclusion
- Smoking
- Active health problems
- Contraindications to MRI scanning
- Bleeding tendency
- Abnormal liver or renal function tests
- Type 2 diabetes
- Evidence of metabolic or viral liver disease
- Alcohol intake \> 21 units per week
- Chronic medication except ones needed for stable hypertension
Key Trial Info
Start Date :
August 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2015
Estimated Enrollment :
82 Patients enrolled
Trial Details
Trial ID
NCT01445730
Start Date
August 1 2011
End Date
June 1 2015
Last Update
June 15 2021
Active Locations (4)
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1
Université Laval
Québec, Canada
2
Helsinki University Central Hospital, Biomedicum
Helsinki, Finland, 00290
3
University of Naples, Federico II, and Faculty of Medicine
Naples, Italy
4
Sahlgrenska Academy at University of Gothenburg and Sahlgrenska University Hospital
Gothenburg, Sweden