Status:
COMPLETED
Comparison of Postprandial Inflammation in Lean and Obese Subjects
Lead Sponsor:
Agroscope Liebefeld-Posieux Research Station ALP
Collaborating Sponsors:
Insel Gruppe AG, University Hospital Bern
Conditions:
Nutritional Intervention
Nutritional and Metabolic Diseases
Eligibility:
MALE
25-50 years
Phase:
EARLY_PHASE1
Brief Summary
The purpose of this study is to quantify the systemic inflammatory and metabolic response of lean subjects and obese subjects to the ingestion of three caloric doses of a high-fat meal.
Eligibility Criteria
Inclusion
- Inclusion Criteria for lean subjects:
- age 25-50
- 20\<BMI\<25
- waist circumference \<94cm
- Inclusion Criteria for obese subjects
- age-matched to healthy subjects
- 30\<BMI\<40
- waist circumference \>102cm
- Exclusion Criteria for lean and obese subjects:
- Physiological or psychological diseases
- Allergies to food or intolerance to high-fat meal
- Vegetarians
- Chronic intake of drugs
- Smokers
- Diabetes mellitus Type I and II
- Debilitating kidney diseases
- Debilitating liver diseases
- Clinically established coronary heart diseases
- Ingestion of vitamins or dietary supplements during the course of the study
Exclusion
Key Trial Info
Start Date :
March 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2013
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT01446068
Start Date
March 1 2011
End Date
January 1 2013
Last Update
June 20 2013
Active Locations (2)
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1
Agroscope Liebefeld-Posieux ALP Research Station
Bern, Canton of Bern, Switzerland, 3003
2
University Hospital Inselspital, Berne
Bern, Canton of Bern, Switzerland, 3010