Status:
COMPLETED
S. Endotoxin, Inflammatory Mediators and MRS Before and After Treatment in MHE
Lead Sponsor:
Govind Ballabh Pant Hospital
Conditions:
Hepatic Encephalopathy
Eligibility:
All Genders
15-70 years
Phase:
NA
Brief Summary
The purpose of this study is to examine S.endotoxins , inflammatory mediators and Magnetic Resonance Spectroscopy (MRS) before and after treatment in patients of cirrhosis and minimal hepatic encephal...
Detailed Description
60 patients of cirrhosis with Minimal Hepatic Encephalopathy (MHE) who fulfills the inclusion \& exclusion criteria will be the part of study. Study patients will be divided in to two groups ( n=30 in...
Eligibility Criteria
Inclusion
- Clinical diagnosis of Cirrhosis (Age 15 yr -70 yr )
Exclusion
- Recent history of gastrointestinal bleed in last 6 weeks
- Active ongoing infection
- Creatinine \>1.5mg%
- Electrolyte impairment. (S. Sodium \< 130 meq/L, S. Potassium 3.5 meq/L or \>5.0meq/L)
- H/O use of psychotropic drugs in last 6 weeks
- Recent alcohol use (\< 6 week )
- H/O TIPS or shunt surgery.
- Hepatocellular Carcinoma
- Severe comorbidity as Congestive Heart Failure, Pulmonary disease, Neurological and Psychiatric problems impairing quality of life
- Poor vision precluding neuropsychological assessment
Key Trial Info
Start Date :
October 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2012
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT01446523
Start Date
October 1 2011
End Date
February 1 2012
Last Update
April 10 2012
Active Locations (1)
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1
BC Sharma
New Delhi, National Capital Territory of Delhi, India, 110060