Status:
COMPLETED
The Effects of Sedative on the Fluid Responsiveness in Critically Ill Patients
Lead Sponsor:
Southeast University, China
Conditions:
Shock
Sepsis
Eligibility:
All Genders
18-80 years
Phase:
PHASE1
Brief Summary
Hypotension and bradycardia are often observed following induction of dexmedetomidine or propofol sedation.Cardiac preload decrease by sedative agents was often considered as one of main causes for th...
Detailed Description
In this clinical trial,the investigators hypothesized dexmedetomidine or propofol infusion in patients with circulatory failure decrease cardiac preload and enhanced preload-dependency and fluid respo...
Eligibility Criteria
Inclusion
- patients with at least one of the clinical manifestations of acute circulatory failure; patients undergoing dexmedetomidine or propofol infusion
Exclusion
- deep venous thrombosis or elastic compression stocking
- an increase in the intra-abdominal pressure confirmed by clinical examination
- serious central nervous system pathology (head trauma, severe dementia, acute stroke, uncontrolled seizures)
- severe liver disease(Child-Pugh class C)
- unstable angina or acute myocardial infarction
- left ventricular ejection fraction less than 30%
- heart rate(HR) less than 50/min, heart block with second- or third degree
- systolic blood pressure (SBP) less than 90 mmHg despite 2 vasopressors infusion continuously before the begin of dexmedetomidine infusion
Key Trial Info
Start Date :
May 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2013
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT01447875
Start Date
May 1 2011
End Date
December 1 2013
Last Update
January 29 2014
Active Locations (1)
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1
Nanjing Zhong-Da Hospital, Southeast University School of Medicine
Nanjing, China, 210009