Status:
COMPLETED
Proton Radiation for Chordomas and Chondrosarcomas
Lead Sponsor:
Abramson Cancer Center at Penn Medicine
Conditions:
Chordomas
Chondrosarcomas
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The objectives of this study are 1) To evaluate the feasibility and acute side effects of proton therapy for chordomas and chondrosarcomas and 2) To evaluate clinical outcomes and long term side effec...
Detailed Description
This trial will be conducted in two phases: a feasibility then a phase II trial. Once feasibility and safety are established in the first 12 pts. the phase II study will begin. Proton therapy at stand...
Eligibility Criteria
Inclusion
- Histologically confirmed diagnosis of chordoma or chondrosarcoma.
- Patients must have no evidence of metastatic disease based on routine imaging (CT or MRI of the chest/abdomen/pelvis, bone scan, etc.)
- Patients must have an ECOG score equal to or less than 2.
- Age ≥ 18 years.
- Patients must be able to provide informed consent.
- Adequate bone marrow function: WBC ≥ 4000/mm3, platelets ≥ 100, 000mm3
- Women of child-bearing potential as long as she agrees to use a recognized method of birth control (e.g. oral contraceptive , IUD, condoms or other barrier methods etc.) Hysterectomy or menopause must be clinically documented.
- Tumors arising in the skull and spine.
Exclusion
- Prior or simultaneous malignancies within the past two years (other than cutaneous squamous or basal cell carcinoma, melanoma in situ or thyroid carcinoma)
- Patients with the following histologies are excluded: melanoma , other soft tissue or bony sarcomas, giant cell tumor aneurismal bone cyst or metastatic lesions from other histologies.
- Pregnant women.
- Actively being treated on any other therapeutic research study.
- Tumors arising outside of the CNS.
Key Trial Info
Start Date :
March 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 4 2025
Estimated Enrollment :
54 Patients enrolled
Trial Details
Trial ID
NCT01449149
Start Date
March 1 2010
End Date
September 4 2025
Last Update
December 5 2025
Active Locations (1)
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1
Abramson Cancer Center of the University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104