Status:
COMPLETED
Rapamycin as a Means of Interference With Reconsolidation of Posttraumatic Stress Disorder-related Traumatic Memory
Lead Sponsor:
University of Texas Southwestern Medical Center
Collaborating Sponsors:
North Texas Veterans Healthcare System
Conditions:
Posttraumatic Stress Disorder
Eligibility:
MALE
18+ years
Phase:
NA
Brief Summary
The purpose of the proposed study is to determine if pairing reactivation of a traumatic memory with a single administration of Rapamycin (e.g., Sirolimus) in men with combat-related Posttraumatic Str...
Detailed Description
Post-traumatic stress disorder (PTSD) is characterized by intrusive memories in the form of unwanted images, nightmares, and flashbacks as the result of being exposed to a traumatic event . Current re...
Eligibility Criteria
Inclusion
- Male Veterans
- Diagnosis of Posttraumatic Stress Disorder related to combat
Exclusion
- Hypersensitivity to Rapamycin
- Organic brain damage (including unresolved Traumatic Brain Injury sequela)
- Substance dependence in the last three months
- On any immunosuppressant therapy
- Prominent suicidal or homicidal features
- Medical conditions: systemic infections, congestive heart failure, renal failure, hepatic failure
Key Trial Info
Start Date :
August 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2010
Estimated Enrollment :
54 Patients enrolled
Trial Details
Trial ID
NCT01449955
Start Date
August 1 2008
End Date
July 1 2010
Last Update
July 18 2018
Active Locations (1)
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1
VA North Texas Healthcare System
Dallas, Texas, United States, 75216