Status:
COMPLETED
Health Technology Assessment of Diagnostic Approaches in Alzheimer's Disease
Lead Sponsor:
Maastricht University Medical Center
Collaborating Sponsors:
Center for Translational Molecular Medicine
Leiden University Medical Center
Conditions:
Neurodegenerative Diseases
Memory Disturbances
Eligibility:
All Genders
18+ years
Brief Summary
Background: New research criteria for the diagnosis of Alzheimer's disease (AD) have recently been developed to enable an early diagnosis of AD pathophysiology by relying on emerging biomarkers. To en...
Eligibility Criteria
Inclusion
- All new consecutive patients of the participating memory clinics who are suspected of having a primary neurodegenerative disease. This means all patients with subjective and/or objective memory complaints.
- CDR 0, 0.5 or 1
- MMSE score must be 20 or higher.
- Availability of a reliable informer or proxy (who visits or contacts the patient at least once a week).
Exclusion
- Normal Pressure Hydrocephalus (NPH)
- Huntington's disease
- Recent Transient Ischaemic Attack (TIA) (\<2 years) or Cerebral Vascular Accident (CVA) or TIA/CVA followed by cognitive impairment (within 3 months)
- History of Schizophrenia, other psychotic disorders (\< 12 months)
- Major depression (\< 12 months)
- Alcohol abuse
- Brain-tumor, epilepsy, encephalitis
- Absence of a reliable informant
- Probably not available for follow-up
Key Trial Info
Start Date :
September 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 1 2013
Estimated Enrollment :
304 Patients enrolled
Trial Details
Trial ID
NCT01450891
Start Date
September 1 2009
End Date
July 1 2013
Last Update
May 28 2015
Active Locations (4)
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1
VU University Medical Center
Amsterdam, Netherlands, 1100 DD
2
Leiden University Medical Center
Leiden, Netherlands, 2333 ZA
3
Maastricht University Medical Center
Maastricht, Netherlands, 6200 MD
4
Radboud University Nijmegen Medical Centre
Nijmegen, Netherlands, 6500 HC