Status:
COMPLETED
Early Detection of Pulmonary Arterial Hypertension Using Cardiac Magnetic Resonance Imaging
Lead Sponsor:
Mayo Clinic
Conditions:
Pulmonary Hypertension
Pulmonary Arterial Hypertension
Eligibility:
All Genders
18-99 years
Brief Summary
Cardiac magnetic resonance imaging has emerged as a potential valuable test for the early detection of Pulmonary Arterial Hypertension. A number of reports have provided some preliminary evidence that...
Eligibility Criteria
Inclusion
- Consecutive patients aged ≥ 18 years with PAH as dictated by a comprehensive examination and echocardiography will be included for enrollment.
Exclusion
- Age \< 18 years
- Pregnancy
- Mechanical ventilation
- Acute or chronic renal failure (creatinine clearance \< 30 ml/min or requiring renal replacement therapy)
- Inability to perform MRI (i.e. claustrophobia, severe obesity (\> 150 kg), device incompatible with MRI)
- Significant arrhythmia that precludes adequate ECG-gating for the MRI (i.e. atrial fibrillation with highly variable cycle lengths)
- Prior heart or lung transplantation
- Left ventricular systolic (ejection fraction \< 50%) or diastolic failure (based on Framingham criteria for heart failure with preserved ejection fraction)
- Significant left-sided valvular disease (≥ moderate aortic stenosis, mitral stenosis, aortic regurgitation, mitral regurgitation) or prior valve surgery
Key Trial Info
Start Date :
August 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2014
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT01451255
Start Date
August 1 2011
End Date
June 1 2014
Last Update
March 17 2016
Active Locations (2)
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1
Mayo Clinic in Florida
Jacksonville, Florida, United States, 32224
2
Mayo Clinic
Jacksonville, Florida, United States, 32224