Status:
COMPLETED
Counterregulatory Hormone Production in Adrenal Insufficiency and Diabetes Type I
Lead Sponsor:
University of Wuerzburg
Conditions:
Addison's Disease
Adrenal Insufficiency
Eligibility:
All Genders
18-65 years
Brief Summary
Patients with adrenal insufficiency also exhibit an adrenomedullary dysfunction. Furthermore, patients who suffer from both, adrenal insufficiency and type I diabetes more frequently report hypoglycem...
Detailed Description
As patients with adrenal insufficiency also exhibit an adrenomedullary dysfunction and patients who suffer from both, adrenal insufficiency and type I diabetes more frequently report hypoglycemia, par...
Eligibility Criteria
Inclusion
- Diagnosis of Addison's disease and/or diabetes mellitus type I or healthy control with normal adrenal function and normal glucose regulation
- Age ≥ 18 years
- Ability to comply with the study protocol
- Capability to perform spiroergometry
Exclusion
- Any contraindication for performing spiroergometry according to the guidelines of the German Cardiac Society:
- acute myocardial infarction
- instable angina pectoris
- symptomatic arrhythmia
- severe and symptomatic stenosis of the aortic valve
- decompensated heart failure
- acute pulmonary embolism
- Acute myocarditis
- Acute pericarditis
- Acute aortic dissection
- main coronary artery disease
- valvulopathies
- electrolyte disturbance
- arterial hypertension (systolic blood pressure \> 200 mm Hg, diastolic BP \> 110 mm Hg)
- Tachyarrhythmia or Bradyarrhythmia
- Hypertrophic cardiomyopathy and other forms of obstructive heart disease
- second or third degree atrioventricular block
- Fever
- Diabetes mellitus Type 2
- Diseases or medication influencing the endogenous levels of plasma catecholamines(e. g. pheochromocytoma, paraganglioma, antidepressants, levodopa)
- Glucocorticoid-pharmacotherapy
Key Trial Info
Start Date :
March 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2013
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT01452893
Start Date
March 1 2011
End Date
December 1 2013
Last Update
January 6 2014
Active Locations (1)
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1
Dept. of Endocrinology and Diabetology, Dept. of Medicine I, University Hospital Wuerzburg
Würzburg, Germany, 97080