Status:
COMPLETED
Endotoxin & Cytokines. Do Protein Loss and Metabolic Effects Depend on Central Nervous System (CNS) Activation of Stress Hormones or on Local Mechanisms in Muscle and Fat?
Lead Sponsor:
Aarhus University Hospital
Collaborating Sponsors:
University of Aarhus
Lundbeck Foundation
Conditions:
Inflammation
Glucose Metabolism Disorders
Eligibility:
MALE
18-70 years
Phase:
NA
Brief Summary
Main objective : The purpose of this study is to prove that the effects of bacterial endotoxin and cytokine TNF-α, on protein loss, fatty acid release, and glucose metabolism depend on two mechanisms...
Detailed Description
PURPOSE: Knowledge about the effects of bacterial endotoxin and cytokines (and inflammation in general) in humans on protein, glucose and lipid metabolism and intracellular signalling in muscle and f...
Eligibility Criteria
Inclusion
- Inclusion Criteria 1. group:
- Male
- 19 \< BMI \< 28
- 18 ≤ Age ≤ 50
- Healthy
- Inclusion Criteria 2. group:
- Male
- 20 \< BMI \< 30
- Age \> 25
- Healthy
- Exclusion Criteria:
- Diseases
- Allergy
Exclusion
Key Trial Info
Start Date :
June 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2013
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT01452958
Start Date
June 1 2010
End Date
January 1 2013
Last Update
January 30 2013
Active Locations (1)
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1
Medical Department MEA, NBG, Aarhus University Hospital
Aarhus, Denmark, 8000