Status:
COMPLETED
Emergency Department Management of Sepsis Patients: A Goal-Oriented Non-Invasive Sepsis Trial
Lead Sponsor:
National University Hospital, Singapore
Collaborating Sponsors:
Singapore Clinical Research Institute
Conditions:
Sepsis
Shock, Septic
Eligibility:
All Genders
21+ years
Phase:
NA
Brief Summary
The purpose of this study is to determine whether the use of a 3-hour protocol utilizing non-invasive hemodynamic optimization treatment strategy results in better outcome and lower hospital costs in ...
Detailed Description
Severe sepsis is a syndrome where the body develops organ dysfunction secondary to uncontrolled inflammatory response to infection. Various resuscitation bundles have been formulated and practised to ...
Eligibility Criteria
Inclusion
- Fulfillment of at least 2 systemic inflammatory response syndrome (SIRS) criteria
- Suspected infection
- Serum lactate ≥3mmol/L
Exclusion
- Age below 21 years
- Known pregnancy
- Prisoners
- Do-not-attempt resuscitation status
- Known severe aortic insufficiency or severe anatomic abnormalities of the thoracic aorta
- Primary diagnosis of trauma, burns, active seizures, acute cerebral vascular accident, acute coronary syndrome, status asthmaticus, major cardiac arrhythmias, active gastrointestinal haemorrhage, seizure or drug overdose
- Requirement for immediate surgery
- Inability to do PLR (e.g. ankylosis of hip joint, severe sciatica)
- Treating physician deems aggressive care unsuitable
- Those unable to give informed consent and unable to comply with study requirements
Key Trial Info
Start Date :
November 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2014
Estimated Enrollment :
122 Patients enrolled
Trial Details
Trial ID
NCT01453270
Start Date
November 1 2011
End Date
March 1 2014
Last Update
September 25 2014
Active Locations (1)
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1
National University Hospital
Singapore, Singapore, Singapore, 119074