Status:
COMPLETED
Wet AMD Recurrence Rate in Patients Stable on Three Month Ranibizumab Dosing
Lead Sponsor:
University Health Network, Toronto
Conditions:
Age Related Macular Degeneration
Eligibility:
All Genders
50+ years
Phase:
PHASE4
Brief Summary
The current norm in clinical practice for the treatment of choroidal neovascular membranes (CNVM) secondary to Age-related Macular Degeneration(AMD) involves monthly injections of Ranibizumab until th...
Detailed Description
In North America, AMD is the leading cause of irreversible vision loss in those over 65 years of age.1 Vascular endothelial growth factor A (VEGF-A) is a potent promoter of angiogenesis and vascular p...
Eligibility Criteria
Inclusion
- Age 50 years or more
- Active primary or recurrent choroidal neovascularization secondary to AMD in the study eye, currently stable on an 'every three month' treatment regimen (established using a treat and extend dosing protocol)
- Best-corrected visual acuity of Counting Fingers or better (Snellen equivalent) in the study eye
- All IVFA lesion types and lesion sizes
- One eye per subject (the "study eye"). If both eyes are eligible, the one with better VA will be selected unless, for medical reasons, the other is more appropriate
Exclusion
- Treatment of the current choroidal neovascular membrane with verteporfin photodynamic therapy (PDT), external-beam radiation therapy, transpupillary thermotherapy, or subfoveal laser photocoagulation (or juxtafoveal or extrafoveal laser photocoagulation
- History of vitrectomy surgery in the study eye
- Individuals with choroidal neovascularization from causes other than AMD
Key Trial Info
Start Date :
November 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2012
Estimated Enrollment :
44 Patients enrolled
Trial Details
Trial ID
NCT01453920
Start Date
November 1 2011
End Date
July 1 2012
Last Update
August 28 2012
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Toronto Western Hospital
Toronto, Ontario, Canada, M5T 2S8