Status:
COMPLETED
Adaptation of Human Gut Microbiota to Energetic Restriction
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Obesity
Metabolic Diseases
Eligibility:
FEMALE
18-65 years
Phase:
NA
Brief Summary
Gut microbiota ecology is altered in obesity and could link obesity and its complications. Bariatric surgery enables a major and sustained weight loss therefore improving obesity related disease. the...
Detailed Description
The prevalence of obesity is rising to an epidemic level. Yet medical and pharmacological treatments have proven their limits. Dietetic modifications contribute to adipose tissue alterations and cross...
Eligibility Criteria
Inclusion
- Obese group
- Inclusion criteria :
- Obesity with BMI\> 40 kg/m² or obesity with BMI between 35 and 40 kg/M² with comorbidities (OSA, type 2 diabetes, hypertension etc…)
- Age: 18-65
- women
- weight stable for three months preceding surgery
- Exclusion criteria :
- Inflammatory disease
- Pregnancy
- Lactose intolerance
- Antibiotherapy in the three months preceding surgery
- cancer
- Drugs (AINS)
- Healthy group
- Inclusion criteria :
- 19\<BMI\<25kg/m²
- Age: 18-65
- women
- non diabetic
- Exclusion criteria :
- Inflammatory disease
- Pregnancy
- Antibiotherapy in the two months preceding the visit
- pregnancy
- Drugs (AINS) in the 48h preceding the visit
Exclusion
Key Trial Info
Start Date :
June 7 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 14 2018
Estimated Enrollment :
140 Patients enrolled
Trial Details
Trial ID
NCT01454232
Start Date
June 7 2011
End Date
September 14 2018
Last Update
March 15 2019
Active Locations (1)
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1
Pitié Salpêtrière Hospital
Paris, France, 75013