Status:
COMPLETED
The Effects of Lowering Dialysate Sodium in Hypertensive Hemodialysis Patients
Lead Sponsor:
Capital Medical University
Conditions:
Hypertension
Arteriosclerosis
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
Unfavorably high sodium intakes remain prevalent around the world. A negative sodium gradient in hemodialysis treatment results in absolute sodium removal via diffusive transport of sodium from the bl...
Detailed Description
A number of studies have shown that lowering dialysate sodium concentration could improve blood pressure (BP) control, and the lower BPs are considered to be a result of an improvement in volume statu...
Eligibility Criteria
Inclusion
- They had been on HD for more than 1 year.
- They had had no clinical cardiovascular disease during 3 months preceding entry into the study, with left ventricular ejection fraction over 40%.
- Their residual daily urine output was lower than 100 ml/day.
- They had achieved their dry weight assessed by bioimpedance technique and clinical examination for at least 3 months.
- A mean interdialytic ambulatory BP of \>135/85 mmHg.
- Averaging the last six available monthly pre-dialysis plasma sodium concentrations over the preceding 12 months \>138mmol/l.
Exclusion
- They had known acute inflammatory event, malignant disease, and the serum albumine\<30g/l.
- They were diabetic and hypotension prone.
Key Trial Info
Start Date :
October 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2011
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT01455974
Start Date
October 1 2010
End Date
September 1 2011
Last Update
October 20 2011
Active Locations (1)
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1
Department of Nephrology, Chao-Yang Hospital, Capital Medical University
Beijing, China, 100020