Status:
UNKNOWN
Effects of Apelin on the Lung Circulation in Pulmonary Hypertension
Lead Sponsor:
Golden Jubilee National Hospital
Collaborating Sponsors:
NHS Lothian
Imperial College Healthcare NHS Trust
Conditions:
Pulmonary Arterial Hypertension
Heart Failure
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of this study is to determine the effects of Apelin on the lung circulation. The investigators hypothesise that Apelin will relax the lung blood vessels and improve the pumping ability of ...
Detailed Description
Apelin is an endogenous peptide with physiological actions in the cardiovascular system and is abundantly expressed in the pulmonary vasculature. Pre-clinical models and preliminary clinical data indi...
Eligibility Criteria
Inclusion
- PULMONARY ARTERIAL HYPERTENSION
- Pulmonary Arterial Hypertension which is Idiopathic, Heritable, associated with connective tissue disease or associated with drugs/toxins
- mean pulmonary artery pressure \>/= 25mmHg
- pulmonary capillary wedge pressure \< 15 mmHg
- normal/reduced cardiac output
- stable
- WHO functional class II - IV
Exclusion
- significant left ventricular dysfunction
- chronic lung disease (FEV1 \< 60% or abnormal CT)
- chronic thromboembolic pulmonary hypertension
- HEART FAILURE
- Inclusion Criteria:
- stable on treatment for 3 months prior to study
- NYHA grade II - IV
- ejection fraction \<35%, left ventricular end-diastolic diameter \> 5.5 cm and/or shortening fraction \< 20%
- Tricuspid regurgitant velocity \>/= 3.0 m/s
- HEALTHY VOLUNTEERS
- Inclusion Criteria:
- mean pulmonary artery pressure \< 25 mmHg
- tricuspid regurgitant velocity \< 2.5 m/s
Key Trial Info
Start Date :
January 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2014
Estimated Enrollment :
63 Patients enrolled
Trial Details
Trial ID
NCT01457170
Start Date
January 1 2012
End Date
January 1 2014
Last Update
July 15 2013
Active Locations (3)
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1
Royal Infirmary Edinburgh
Edinburgh, United Kingdom, EH16 4SA
2
Golden Jubilee National Hospital
Glasgow, United Kingdom, G81 4HX
3
Hammersmith Hospital
London, United Kingdom, W12 0HS