Status:
COMPLETED
Proton Pump Inhibitors and Dysbiosis in Cirrhosis
Lead Sponsor:
Hunter Holmes Mcguire Veteran Affairs Medical Center
Conditions:
Cirrhosis
Healthy
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
The purpose of this study is to find out whether the use of medications that suppress acid in your stomach can change the composition of your bowel bacteria.
Eligibility Criteria
Inclusion
- Inclusion Criteria for PPI initiation study:
- Cirrhosis not on current PPI or acid suppressive therapy
- No systemic antibiotics or probiotics
- Exclusion Criteria for PPI initiation study:
- On systemic antibiotics
- On PPI or acid suppression therapy already
- unable to give informed consent
- Allergy to proton pump inhibitors
- Inclusion Criteria for PPI withdrawal study:
- Cirrhosis on current PPI for an FDA-unapproved indication
- No systemic antibiotics or probiotics
- Exclusion Criteria for PPI withdrawal study:
- On systemic absorbable antibiotics
- On PPI or acid suppression therapy for an FDA-approved indication
- unable to give informed consent
- unwilling to withdraw PPI
Exclusion
Key Trial Info
Start Date :
October 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2018
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT01458990
Start Date
October 1 2011
End Date
February 1 2018
Last Update
March 19 2018
Active Locations (1)
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1
Hunter Holmes McGuire VA Medical Center
Richmond, Virginia, United States, 23249