Status:
COMPLETED
Effects of FODMAPs on Small Bowel Water Content: an MRI Study
Lead Sponsor:
University of Nottingham
Conditions:
Healthy
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
Some carbohydrates, particularly fructose, the sugar found in fruit and bread may cause bloating, pain and erratic bowel habits (diarrhoea and constipation) particularly in patients suffering from the...
Detailed Description
Title: Effects of FODMAPs (Fermentable Oligo-, Di-, and Mono-saccharides, And Polyols) on small bowel water content: an MRI study 1. Background. FODMAPs consist of fructose, lactose, fructo- and gala...
Eligibility Criteria
Inclusion
- Apparently healthy: no medical conditions which might effect study measurements.
- No reported participation in another nutritional or biomedical trial 3 months before the pre-study examination or during the study.
- Age ≥ 18 and ≤ 60 year at pre-study investigation.
- Body mass index (BMI) ≥ 18.0 and ≤ 30.0 kg/m2
- No reported participation in night shift work two days prior to pre-study investigation or during the study. Night work is defined as working between midnight and 6.00 AM.
- Strenuous exercise ≤ 10 hours per week.
- Gender: male or female
- Consumption of ≤ 21 alcoholic drinks in a typical week
- Currently not smoking
- Suitable for MRI scanning (e.g., absence of metal implants, infusion pumps and pacemakers) as assessed by the attached MRI safety questionnaire.
Exclusion
- \- use of medication which interferes with study measurements or bowel motility (as judged by the study physician).
- Antibiotics in the 3 weeks before pre-study examination
- Probiotics or during the study
Key Trial Info
Start Date :
October 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2012
Estimated Enrollment :
17 Patients enrolled
Trial Details
Trial ID
NCT01459406
Start Date
October 1 2011
End Date
December 1 2012
Last Update
December 19 2012
Active Locations (1)
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1
NDDC BRU and Sir Peter Mansfield Magnetic Resonance Centre
Nottingham, Nottinghamshire, United Kingdom, NG72UH