Status:
COMPLETED
Study to Identify the Genetic Variations Associated With Phantom Limb Pain
Lead Sponsor:
Henry M. Jackson Foundation for the Advancement of Military Medicine
Collaborating Sponsors:
Uniformed Services University of the Health Sciences
Conditions:
Phantom Limb
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of this study is to determine if there is a genetic component to phantom limb pain. DNA will be analyzed for single nucleotide polymorphisms (SNPs) between the control and phantom limb pai...
Detailed Description
Most patients (90-95%)with major limb amputations experience a phantom limb--the vivid impression that the limb is still present. In many cases, the sensation is painful for reasons that are currently...
Eligibility Criteria
Inclusion
- Chronic PLP Group:
- At least 18 years of age.
- Written informed consent and written authorization for use or release of health and research study information
- Single or multiple upper and/or lower limb amputation
- At least three months post-amputation
- Ability to follow study instructions and likely to complete required visit(s)
- Experienced PLP for at least one month and at least 3 times per week
- Phantom limb pain differentiated from residual limb pain by physical exam.
- Subjects taking blood thinners or other medications that do not increase risk during a blood draw.
- Non-Chronic PLP Group:
- At least 18 years of age.
- Written informed consent and written authorization for use or release of health and research study information
- Single or multiple upper and/or lower limb(s) amputation
- At least three months post-amputation
- Ability to follow study instructions and likely to complete required visit(s)
- Experienced PLP less than 10 times total and/or for less than two weeks
- Subjects taking blood thinners or other medications that do not increase risk during a blood draw.
Exclusion
Key Trial Info
Start Date :
March 1 2012
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 6 2023
Estimated Enrollment :
726 Patients enrolled
Trial Details
Trial ID
NCT01462448
Start Date
March 1 2012
End Date
August 6 2023
Last Update
August 12 2025
Active Locations (1)
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1
Walter Reed National Military Medical Center (WRNMMC)
Bethesda, Maryland, United States, 20889